Fire board dispatched Companies to the 100 block of W. Berkley at 03:25 for the possible dwelling fire with entrapment. Units arriving o/s reported a 2 story brick mor dwelling with heavy fire 1st & 2nd floor rear with heavy smoke throughout. They also confirmed entrapment of an infant in the 2nd floor front bedroom. Firefighters entered the bldg for fire supression and search and rescue. They found the infant in his crib in the 2nd floor front bedroom and rushed him out to the medics, who transported to Fitz. The 16 month old was pronounced at the hospital a short time later. Heavy fire in the 1st floor rear had spread to the 2nd floor through the ventilation system. Companies had 2 lines in service and made a quick knock on the bulk of the fire. The father and 2 other children ages 8 & 10 escaped the house unharmed.