The box assignment was struck out at approximately 0340. Engine-25 arrived o/s reporting a 4 story 75 x 150 vacant bldg, fully involved. All companies to lead off with heaviest water lines. The 2nd alarm was struck on arrival. The fire eventually went to 7 alarms with several exposure dwellings becoming involved in fire also. All companies were in svc with numerous master streams, from the ground and roof tops. 2 victims were transported to temple with burns & smoke inhalation. 1 Fire Fighter was transported with unk injuries.